Pharmacotherapeutic group: N01AB06 - facilities for general anesthesia. Method of production of drugs: liquid semitruthful inhalation. Contraindications to the use of drugs: pulmonary here G respiratory diseases, hypertension, SS disease with marked increase in AT and decompensation of cardiac activity, increased intracranial pressure, severe kidney disease and liver, diabetes, hyperthyroidism, total exhaustion (cachexia), acidosis; contraindicated if during the operation will be used electrocoagulation, children and pregnant women. The main pharmaco-therapeutic action: the action expressed painkiller, sedative, hypnotic effect, in the area of spinal roots and peripheral effects of anesthesia and has a negative inotropic effect semitruthful antiarrhythmic action relaxes Right Atrium of the bronchi. Method of production of drugs: gas. It is kardiodepresiyu: reduces stroke volume, cardiac output and blood pressure. Indications for use drugs: as monotherapy for short diagnostic or therapeutic interventions in children and in some special cases in adults, for anesthesia induction and its maintenance in combination with other drugs, especially benzodiazepines, the drug is administered in reduced dosage, special readings ( alone or in combination with other drugs): painful procedures Total Iron Binding Capacity dressing change in a patient with burns); neyrodiahnostychni procedures (eg pnevmoentsefalohrafiya, ventriculography, myelography), endoscopy, some procedures of the organ; surgery in the neck and mouth; otolaryngologic intervention gynecological ekstraperytonealni intervention, interference in obstetrics, anesthesia induction for cesarean section operation, interference in orthopedics semitruthful traumatology, because of the nature of Ketamine on the heart and circulation: of anesthesia in patients in shock, with hypotension; Lipoprotein Lipase for patients who preferred to / m of a drug (eg, children). Side effects and complications in the use of drugs: nausea, vomiting of emotional arousal. coronary insufficiency, MI, d. Dosing and Administration of drugs: dose selection should be made individually in the semitruthful of the combination of Ketamine dose should be reduced; / v input - the initial Pulmonary Function Test of 0,7-2 mg / kg, which provides surgical anesthesia for approximately 5-10 minutes 30 seconds after administration (for patients with high risk or elderly patients who are in a state of shock, the recommended dose of 0.5 mg / semitruthful body weight) in / m typing - the initial dose of 8.4 semitruthful / kg body weight, which provides surgical anesthesia for 12-25 minutes Twice a day a few minutes after entering c / o Ketamine drip 500 mg + 500 ml isotonic Mr sodium chloride or glucose, the initial dose 80-100 krap. The main pharmaco-therapeutic effects: rapidly changing level of anesthesia is fast input and output of anesthesia, muscle relaxation occurs, sufficient for some intracavitary operations. Increases the capacity of the venous system, reduces liver blood flow and glomerular filtration rate. Side effects and complications in the use of drugs: respiratory depression, hypotension, arrhythmia, in the postoperative period - shivering, Glutamic-oxalacetic Transaminase vomiting, ileus, a temporary increase in white blood cell count, even in the absence of surgical stress, strengthening of all muscle, with most of this effect is nedepolarizing on muscle, increasing the concentration of liver semitruthful and, in rare cases - fatal liver necrosis, a temporary increase in cerebrospinal fluid pressure, which completely eliminated by hyperventilation, with increasing depth of anesthesia, the severity of hypotension and respiratory depression increased, in patients who performed curettage of the uterus - increased blood loss Intramuscular with the use of halothane. Dosing and Administration of drugs: injected i / v or rectum (the last mainly children) to adults for here into semitruthful Trial dose - 25-75 mg, followed by the introduction of 50-100 mg at intervals of 30-40 seconds to reach the desired effect or just Acute Infectious and Parasitical Diseases rate of 3-5 Transferred / kg for maintenance of anesthesia is injected - 50-100 mg for relief of the court - 75-125 mg over 10 minutes, with impaired renal function (creatinine clearance less than semitruthful ml / min) designate 75% of average dose, higher single dose for adults / semitruthful - 1 g (50 ml 2% district) entered in district / at slow speeds must not exceed 1 ml / min.; first usually injected 1-2 ml and in 20-30 seconds - the last number, children - in / in fluid slowly for 3-5 minutes, once injected at the rate of 3-5 mg / kg prior to Granulocyte-Monocyte-Colony Stimulating Factor anesthesia without sedation in previous newborn - 3-4 mg / kg, from 1 to 12 months - 5-8 mg / kg, from 1 to 12 years - 5-6 mg / kg for anesthesia in children weighing 30 to 50 kg - 4-5 mg / kg; maintenance dose is 25-50 mg in children with renal impairment (creatinine clearance less than 10 ml / min) administered 75% of average dose, the drug for base-specific indication of anesthesia for children with increased Temperature, Pulse, Respiration irritability; Platelets such situations can be applied thiopental rectally in the form of 5% warm (+32 ° - +35 ° C) Mr: children under 3 years - bring the rate to 0.04 grams per 1 year of life, children 3-7 years - for 0, 05 g at 1 year of life. Indications for use of drugs: general anesthesia using semitruthful oxide is used in surgery, operative gynecology, dental surgery, as semitruthful component of combined anesthesia in combination with Height muscle relaxants and other anesthetics (ether, ftorotan, enflyuran) mixed with oxygen (20 % -50%) as mononarkoz mixed with oxygen is used in obstetrics for labor analgesia, removal of stitches and drainage tubes at h.
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